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Starting PONVORY® Treatment | PONVORY® (ponesimod)

Before you can start PONVORY® safely, your healthcare professional may ask you to complete a few tests


These tests include:

  • ecg

    An electrocardiogram, or ECG, to measure how your heart is working

  • blood_work

    Blood work to test your overall health and liver function, and to check for antibodies to varicella-zoster virus

  • eye_exam

    An eye exam to determine your risk for developing issues with vision, like macular edema

first dose of PONVORY®  at home

Most people can take their first dose of PONVORY® at home instead of in a doctor's office or another healthcare setting

Depending on your pretests and/or cardiac history, you might also be asked to complete first-dose, 4-hour monitoring, which is required for people with certain cardiac conditions (slow heart rate, certain types of heart block, and heart attack or heart failure occurring >6 months prior to treatment initiation and in stable condition). Your healthcare professional will inform you if this monitoring is required.

Getting your PONVORY® 14-Day Starter Pack and Maintenance Dose


After completing your pretests, you and your healthcare professional will determine when you’re ready to begin therapy. In preparation for your first dose of PONVORY®, you will receive a  PONVORY® 14-Day Starter Pack, a separate bottle that contains your 20 mg maintenance dose of PONVORY®, and enrolled patients will also receive an educational kit from the Wellness Companion Program that provides information for taking your medication.

starting pack

The Starter Pack is used for patients beginning treatment with PONVORY®. You will start treatment with a low dose of medication, and gradually increase the dose over 14 days, carefully following the instructions in the Starter Pack. After you finish taking the pills in the Starter Pack, you will continue treatment on Day 15 using the 20 mg maintenance dose of PONVORY®, which will be provided in a separate prescription bottle.

When you are finishing the bottle of your maintenance dose of 20 mg, you can work with your specialty pharmacy to help fulfill future shipments of your medication.

For more information about the Dosing and Administration of PONVORY®, please refer to the full Prescribing Information and Medication Guide.

Janssen CarePath Trial Offer for PONVORY®


Free 14-Day Starter Pack and 30-Day maintenance supply for eligible patients

The Trial Offer helps you become familiar with PONVORY®. At the end of the program, you and your healthcare provider decide whether to continue treatment. To be eligible, you must have been prescribed PONVORY® and be 18 years of age or older. One (1) use is allowed per lifetime.

This trial program is open to patients who have commercial insurance, government insurance, or no insurance coverage. However, there is no guarantee of continuous accessibility after the program ends. Terms expire at the end of each calendar year and may change.

To learn more, talk to your healthcare professional.

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